I just finished support work that required that I install a different version of AutoCAD/Civil 3D than what I normally use for development.
After the C3D install was complete, here's what I did to get ASE actually running on an existing project I worked with on a support request:
Added ASE Civil to the AutoCAD Startup Suite
Opened a drawing
Clicked "Always Load" on the security dialogs (5 of them?)
Yep. That's right. 4 steps is all it took. Consider though that 2 of those steps involved starting C3D & opening a drawing (After ASE configuration was complete). 1 step was a one-time, 5-click process.
Set the AutoCAD options needed to run ASE
Unloaded legacy ASE ribbons
Loaded the correct CUI into the active Workspace
All those configuration steps required in previous versions of ASE Civil are history now.